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Identification of non-conventional small molecule degraders and stabilizers of squalene synthase 

11-08-2023 09:30 AM

selective degraders and stabilizers of squalene synthase (SQS) by KY02111 was time-, dose- and proteasome-dependent, enhancing the natural SQS degradation and leading to reduced cellular cholesterol ester levels. Surprisingly, compounds designed to be PROTACs led to the stabilization of SQS by blocking its proteasomal degradation.

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2023.06.02.543387v1.full.pdf   1.26 MB   1 version
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