Molecular glues are small molecules, typically smaller than PROTACs, and usually with improved physicochemicalproperties that aim to stabilise the interaction between two proteins. Most often this approach is used toimprove or induce an interaction between the target and an E3 ligase, but other interactions which stabiliseinteractions to increase activity or to inhibit binding to a natural effector have also been demonstrated. Thisreview will describe the effects of induced proximity, discuss current methods used to identify molecular gluesand introduce approaches that could be adapted for molecular glue screening.
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