Hi All,
Longtime SLAS conference attendee just getting back into supporting screening technologies. I recently started a new role at Exciting Instruments where we've managed to "free" confocal fluorescence spectroscopy from expert academic labs, dark rooms, open laser optical benches, etc. and package the hardware in a closed, integrated benchtop system with intuitive and approachable software. These techniques (primarily fluorescence correlation spectroscopy and single molecule FRET) are decades old with rich publication histories, but have largely been inaccessible to screeners, especially in industry contexts.
One area that gained immediate traction was in characterizing and quantifying (e.g. binding affinity and cooperativity) ternary complex formation by induced proximity agents such as molecular glues and PROTACs. The method is rapid, low target consumption, applicable to very low affinity interactions, and has low background and matrix interference. No booth this time, but I'll be at the conference if anyone would like to have a quick chat. Drop me a line via the platform or email!
Cheers,
Jake
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Jake Isaacs, PhD
Exciting Instruments www.excitinginstruments.com
jake.isaacs@excitinginstruments.com
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