Proximity Assays

Molecular glues are small molecules, typically smaller than PROTACs, and usually with improved physicochemical
properties that aim to stabilise the interaction between two proteins. Most often this approach is used to
improve or induce an interaction between the target and an E3 ligase, but other interactions which stabilise
interactions to increase activity or to inhibit binding to a natural effector have also been demonstrated. This
review will describe the effects of induced proximity, discuss current methods used to identify molecular glues
and introduce approaches that could be adapted for molecular glue screening.